February 1, 2023

These seminars are focused on fostering engagement between speakers and students. This is a great opportunity to learn about and get more engaged in neural engineering, regardless of what your previous background may be.

Friday, February 10th, 3-4 PM in SAV 264: Hardware and software for high-density, brain-wide electrophysiology

Dr. Josh Siegle, PhD – Senior Scientist at the Allen Institute

RSVP (strongly encouraged): https://forms.gle/Ra8EN1L9r2Ao6rLD6

Zoom Link: https://washington.zoom.us/j/99186063950?pwd=TmhIMHU0UWlGWTRkeVlBMVBON1ZkUT09


Extracellular electrophysiology remains the gold standard for measuring neural activity, as only ephys can reliably detect individual action potentials with sub-millisecond temporal resolution and brain-wide reach in behaving subjects. However, until recently, the best available tools could only sample from a few hundred electrodes simultaneously, limiting the scope of questions that could be addressed with this technique. In collaboration with engineers at imec and scientists at HHMI Janelia Research Campus and University College London, the Allen Institute helped develop a new high-density recording device called “Neuropixels.”

Neuropixels have now been distributed to more than 600 labs, where they can be used to routinely record from thousands of neurons across dozens of brain regions, increasing both the throughput and richness of ephys experiments. At the newly launched Allen Institute for Neural Dynamics, we are pushing the limits of what is possible with Neuropixels by refining techniques for aligning and inserting these probes. In addition, I am leading the effort to build the Open Ephys GUI, an efficient and flexible application for acquiring, processing, and visualizing multichannel ephys data. These tools have already yielded numerous exciting discoveries, and they make it easier than ever for researchers to start running their own cutting-edge ephys experiments.

There will be a Q&A at the end of the talk, and refreshments provided!