February 12, 2024

Biomaterials/Nanomaterials in Tissue Engineering
(Credits: 3, Spring quarter 2024, Tues and Thurs 2:30-3:50 pm, Low 216)

MSE482-582-Biomaterials-Tissue Engineering 2024

Instructor: Miqin Zhang
Professor, Department of Materials Science and Engineering
Professor, Department of Neurological Surgery
Adjunct Professor, Bioengineering, Radiology, Orthopaedics & Sports Medicine University of Washington
Office Hours: 4:30-5:30 Tues in 302L Roberts
Tel: (206) 616-9356
Fax: (206) 543-3100
Course website: https://canvas.uw.edu/courses/1548599
Email: mzhang@u.washington.edu
Faculty website: http://faculty.washington.edu/mzhang
Course Description
The objective of this course is to provide students a fundamental understanding of biomaterials, their implant applications and design consideration. This course covers the fundamentals of the synthesis, properties, and biocompatibility of metallic, ceramic, polymeric, composite, and biological materials, and their applications for both hard and soft tissue replacement, and controlled drug delivery. This course will also provide students a broad understanding of cutting-edge developments in nanomaterials and their potential applications in tissue engineering.

Course outline
1. Introduction : (1.5 week)
Introduction to biomaterials: The structures of materials Characterization of materials
2. Classes of biomaterials (1.5 weeks)
Biological materials
3. Tissue response to materials (1 week)
Host response to biomaterials
Material response to the host
Biocompatibility of materials
4. Biomaterials (2 weeks)
Soft tissue replacement I: sutures, skin, maxillofacial implants
Soft tissue replacement II: Blood interfacing implants
Hard tissue replacement I: long bone repair
Hard tissue replacement II: joints and teeth
Biomaterials in tissue engineering
5. Nanomaterials in tissue engineering (4 weeks)
Nanomaterial-cell interactions

Electrospinning technology for nanofibrous scaffolds
Nanomaterials for skeletal, muscle, nerve, and heart tissue engineering
Nanomaterials for stem cell tissue engineering
Nanomaterials for drug delivery
Magnetic nanoparticles for tissue engineering
Nanoparticles/nanotubes/nanowires for cellular engineering

Biomaterials: An Introduction, Joon B. Park and Roderic S. Lakes, 3rd Edition, Plenum Press 2007.
Reference books
• Materials Science and Engineering an Introduction, William D Callister, Jr., 6th, or 7 th or 8th Edition
• Biomaterials Science: An Introduction to Materials in Medicine, 2nd Edition. Buddy Ratner, Allan S. Hoffman, Frederick J. Schoen, and Jack E. Lemons, Academic Press, 2004 or 2013.
• Essential Biomaterials Science, David William, Cambridge University Press, 2014
• Frontiers in Tissue Engineering, Edited by Charles W. Patrick Jr, Antonios G. Mikos, and Larry V. McIntire, Pergamon, 2011.

Homework and exams
Homework: Five assignments
Midterm: multiple-choice questions
Final: Term paper

Students enrolled in MSE582 are required to carry out additional literature reviews, include additional Discussion/Future directions in the term paper, and give an oral presentation at the end of the course. This is not required for those enrolled in MSE482.

MSE482 MSE582
Homework 40% 35%
Midterm 20% 20%
Final term paper 40% 35%
Final oral presentation 10%
The whole class will meet at the last day of the class to hear and question the oral presentations by the students in MSE 582.

First day of class: Tues, March 26
Midterm: Tues, May 7
Final exam (Term paper): May 23
Presentations: May 28 and May 30. The whole class (both MSE482 and MSE582) will participate in the presentations and hear and question the oral presentations from students in MSE 582.